Deskripsi:
Crown god [Phaleria macrocarpa (Scheff.) Boerl] is one of the medicinal plants that have been used empirically to treat various types of diseases such as cancer, heart disease, diabetes, gout, rheumatism, kidney, high blood pressure, eczema, acne, insect bites and wounds. Crown of god fruits contain flavonoids which suspected has the effect of hypoglycemic. This study investigated the effect of aethyl acetate extract crown god fruits [Phaleria macrocarpa (Scheff.) Boerl] against renal and heart damage induced by a high-fructose diet (10% v/v) in rats ad libitum for 8 weeks. The rats (n = 42) were divided into seven groups (of six each); normal control, negative control, captopril 10 mg/kg BW and exract methanolic P. Marcocarpha (PM) at the dose 0 start at week 6 until week 8 and 1 g/kg BW for 8 weeks. After completion of treatment schedule rats from each group were anesthetized with urethane (120 mg/100 gm, i. p.). Rats were sacrified to obain their kidney and liver for routine staining. Treatment with PM (methanolic extract) and captopril significantly reduced diameter of vena centralis and reduced the glomerular hypertrophy (p<0,05)
Universitas Esa Unggul
Penulis:
- Aprilita Rina Yanti Eff ( 215020572 )
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