Deskripsi:
The present study was carried out to investigate the antihypertensive effect and Angiotensin Converting Enzyme activity of methanolic extract of Phaleria macrocarpa (Scheff) Boerl fruits in rats . Hypertension was induced experimentally by 10% w/v fructose diet ad libitum for 8 weeks. P. marcocarpa was given at the dose 0.5, 1 and 2 g/kg BW start at week 6 until week 8 and 1 g/kg BW for 8 weeks. Blood pressure was measured at baseline and at every weeks for 8 weeks using tail-cuff plethysmography. After completion of treatment schedule rats from each group were anesthetized with urethane (120 mg/100 gm, i. p.). Blood was collected and then centrifugated to obtain plasma and later store at-700C for analysis activity ACE plasma. The results suggests that methanol extract of Phaleria marcocarpha could prevent the development high blood pressure and normalized blood pressure in rat induced by diet rich in fructose. The results tend to suggest that methanol extracts of possesses antyhipertensive activity, through inhibition of angiotensin converting enzyme.
Universitas Esa Unggul
Penulis:
- Aprilita Rina Yanti Eff ( 215020572 )
- Maksum Radji
- Abdul Munim
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